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Ostarine (MK-2866) Profile

by John Connor ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide) Imagine a compound that elicits steroid like muscle building effects with little or no androgenic side effects, a compound that packs on lean body mass while lowering body fat in individuals who don’t even weight train, a compound that is safe to use for months and may even be used by…
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August 12, 2017 0

YK11: a SARM and myostatin inhibitor in one

Japanese researchers are doing experiments with a new SARM which, if the first publications are anything to go by, has a stronger anabolic effect than classic steroids such as DHT. YK11 attaches itself to the androgen receptor, causes few androgen effects and inhibits – the researchers haven’t quite worked out how – the effect of…
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August 12, 2017 0

Ostarine Update

by Mike Arnold Prior to the release of any new drug, there is always a measure of uncertainty regarding both its efficacy and safety in the target population. This is particularly true of those drugs being sold specifically for off-label use in conjunction with untested dosing recommendations and/or methods of administration. Upon its release, Ostarine…
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August 12, 2017 0

Is [D-Lys (3)] GHRP-6 A Potential Diet Aid?

by Anthony Roberts I’m not entirely sure why [D-Lys (3)]GHRP-6 hasn’t made an appearance on the underground market yet, or at least been experimented with more widely. I’m guessing it’s because, in simplest terms, it can be thought of as the opposite of GHRP-6. Hence, instead of looking at a drug that will release growth…
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May 18, 2016 0

Hexarelin Explained

by Anthony Roberts Hexarelin is a growth hormone secretagogue developed by Mediolanum Farmaceutici, and as its name might suggest, is is a hexapeptide that causes the body to release more growth hormone. It’s bioavailable through numerous methods of administration (in descending order of potency): intravenous, subcutaneous, intranasal (don’t bother), and oral (don’t bother) administration. (1)


May 18, 2016 0

RAD-140 SARM Explained

by Anthony Roberts (a profile taken from his SARMS and Peptides e-book) RAD-140 is a Selective Androgen Receptor Modulator produced by Radius Health, Inc. This is one of those compounds that looks almost too good to be true. I’ll be upfront about it and say that I haven’t used it, but many have, so there…
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April 29, 2016 0

Exploring New S.A.R.M. Technology RAD-140

by Mike Arnold S.A.R.M’s, or selective androgen receptor modulators, as they are called, have become all the rage among pharmaceutical researchers looking to cash in on the next-generation of low-risk anabolics. With a potentially high degree of selectivity for muscle over other bodily tissues, their selling point lies in the ability to provide steroid-like effects…
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January 4, 2016 0

Tamoxifen works differently

The working mechanism of anti-oestrogen tamoxifen citrate – active ingredient of Nolvadex – is more complex than underground manuals would have you believe. Researchers at Duke University discovered this when they did tests on cells. And their findings are probably valid for all SERMs – so also for clomiphene, raloxifene and toremifene. SERM’s SERMs have…
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September 23, 2015 0

Exemestane makes you slimmer and more muscular

Exemestane, the active ingredient in Pfizer’s Aromasin [structural formula shown below], truly is a body recompositioning drug. At least it is if you’re prepared to accept the results of an Italian study in which 33 women used exemestane for a period of 2 years.


September 23, 2015 0

The Battle of the Aromatase Inhibitors

by Mike Arnold There has been considerable debate as to which of the 3rd generation aromatase inhibitors (anastrozole, exemestane, and letrozole) possesses the most ideal risk to benefit ratio; a question which has thus far been difficult to answer due to significant diversity in individual needs, circumstances, and priorities. While most bodybuilders tend to focus…
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August 14, 2015 0

GW-501516 – The Original Fat-burning, Performance Enhancing SARM

by Mike Arnold Accelerated fat loss, increased muscular endurance, improved metabolic health; these are just a few of the ways in which GW-5015156 can benefit our bodybuilding progress. So, it wasn’t surprising when it became all the rage back when it was first released 5 or so years ago, but what was surprising was its…
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July 21, 2015 0

MK-677 – ‘The Best Growth Hormone Secretagogue?’

by Mike Arnold As bodybuilders, we tend to take an interest in any drug which promises to move us one step closer to realizing our goals. Whether the claims are big or small, most new PED’s are welcomed into the fold with a certain degree of excitement and expectation, at which point they are used,…
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June 19, 2015 0

Understanding S.A.R.M.S – Part 2

by Mike Arnold For those of you who didn’t read the first part of this article, allow me to bring you up to speed. Over the last few years we have seen several S.A.R.M’s enter the marketplace, some of which are now fairly well known and others which we are just starting to learn about.…
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June 15, 2015 0

Understanding S.A.R.M.S – Part 1

by Mike Arnold Whenever the subject of S.A.R.M’s is mentioned during conversation, most people tend to think of steroids, or more specifically “steroid alternatives”. This is understandable, given that this class of drugs was originally developed for this purpose, but unlike steroids, S.A.R.M’s are no one trick pony. Muscle growth, elevation of growth hormone levels,…
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June 12, 2015 0

GW-501516 Explained

THE ULTIMATE PERFORMANCE ENHANCER GW-501516 is a drug that acts as a PPARδ modulator. GW-501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ. GW-501516 activates the AMP-activated protein kinase…
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June 8, 2015 0

Combining IGF-1 and GH

It would of course be expensive, but in theory there’s a lot to be said for combining growth hormone [structure shown below] and IGF-1, writes the Dutch endocrinologist Joop Janssen in an article in Reviews in Endocrine Metabolic Disorders. The article is worth looking at if you’re a chemical athlete.


May 31, 2015 0

Growth Hormone Peptides Explored

by Mike Arnold GHRP-6: Growth hormone releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more Growth Hormone. GHRPs have a 2-fold mechanism of action, in that they cause an…
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May 25, 2015 0

Peptide Long R3 IGF-1

The use of peptides by bodybuilders is still relatively new… so in an attempt to find out more about their applications and benefits I interviewed one of the premier research scientists at a lab responsible for their production. In the weeks ahead I will examine many of these substances, but I thought I would start…
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May 25, 2015 0

Anastrozole, Exemestane, and Letrozole

by Mike Arnold There has been considerable debate as to which of the 3rd generation aromatase inhibitors (anastrozole, exemestane, and letrozole) possesses the most ideal risk to benefit ratio; a question which has thus far been difficult to answer due to significant diversity in individual needs, circumstances, and priorities. While most bodybuilders tend to focus…
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May 25, 2015 0

SARM LGD-4033

by Mike Arnold For those who are unfamiliar with the term S.A.R.M, let me fill you in. S.A.R.M.’s, which is short for selective androgen receptor modulators, are a new class of drugs designed to provide the anabolic (i.e. tissue building) benefits of steroids, but without the androgenic, estrogenic, and in many cases, cardiovascular side effects…
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May 24, 2015 0

SARM MK-2866 (Ostarine)

SARM MK-2866 (Ostarine) by Mike Arnold S.A.R.M.S represent a new and exciting category of performance enhancing drugs which are unique to the PED marketplace. For those of you who are unfamiliar, we will begin with a brief introduction. The word SARM is short for “selective androgen receptor modulator” and as the term suggests, this class…
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May 24, 2015 0

Exploring Aromatase Inhibitors

Exemestane and its uses Half life: 9 hours Exemestane (Aromasin) is a Type 1 inhibitor and so therefore is a steroidal inhibitor or suicidal aromatase inhibitor. It’s called this because it lowers estrogen production in the body by attaching to the aromatase enzyme, and permanently deactivating it, and being a steroidal type 1 inhibitor it…
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May 20, 2015 0

What are Peptides?

Peptides are chains of amino acids joined by what chemists call amide bonds, although biologists typically call them peptide bonds instead. Large peptides are called proteins and are ubiquitous — all forms of life on Earth have proteins. The term peptide is usually though not invariably reserved for shorter chains of amino acids such as…
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May 20, 2015 0

Growth Hormone (hGH) Peptides Explored

by Mike Arnold GHRP-6: Growth hormone releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more Growth Hormone. GHRPs have a 2-fold mechanism of action, in that they cause an…
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May 4, 2015 0

Hexarelin Peptide Explored

by Mike Arnold Hexarelin belongs to the category of drugs known as GHRP’s (growth hormone releasing peptides), which are also sometimes referred to as GH secretagogues. They include GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Hex’s primary function is to stimulate the pituitary gland to produce more growth hormone. Like the other GHRPs, it has a 2-fold…
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May 4, 2015 0

Fat loss and Triiodothyronine (T3)

by Mike Arnold Triiodothyronine, also known as T3, is most frequently used in the BB’ing community as a fat loss agent; a job it accomplishes quite effectively. In fact, no other compound used today, aside from perhaps DNP, has the potential to burn body fat more quickly. However, T3 is non-discriminatory when it comes to…
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May 4, 2015 0

Ipamorelin Stimulates hGH

by Mike Arnold Belonging to the category of drugs known as GH secretagogues, Ipamorelin’s primary function is to stimulate the release growth hormone from the pituitary gland. Its fairly recent entrance into the marketplace has earned it the distinction of being a 3rd generation GHRP, noted for exhibiting several unique characteristics which differentiate it from…
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May 4, 2015 0

Clomiphene Citrate (Clomid) and PCT

by Mike Arnold Nearly every BB’r is familiar with the name. It is one of the oldest, yet most effective drugs for the treatment of both testosterone and sperm deficiency. In the medical community it has long been established as the gold-standard for inducing ovulation in women and increasing sperm count & motility in men.…
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May 4, 2015 0

Peptides & Bodybuilding

by Mike Arnold It has been about a decade since peptides were introduced to the BB’ing community on a large scale. Prior to that time, there were rumblings of IGF-1 being circulated among some of the top pros, but by and large, this class of drugs was not yet discussed or available to the public.…
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May 4, 2015 0

IGF-1 Explored

by Mike Arnold There is no denying that growth hormone is one of the most popular BB’ing drugs in use today and for good reason. It not only enhances the rate of fat loss, but leads to improvements in muscular size; two vital aspects of this sport, to be sure. However, one significant difference between…
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May 4, 2015 0

Introduction to Pramipexole

by Mike Arnold Diagnosing the Problem In today’s ultra-competitive society, the use of performance enhancing drugs in sport has become commonplace, enabling athletes to attain a degree of athletic prowess inconceivable to previous generations. While the performance advantages associated with a pharmaceutically altered state are clear, it does not come without risk. Whether one chooses…
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May 4, 2015 0

Introduction to Exemestane

by Mike Arnold Estrogen and the Bodybuilder The human body is an incredibly complex and precise organism, capable of self-regulating all aspects of its internal environment down to the most minute level of functioning. Under normal circumstances this highly interconnected corporal collaboration runs effortlessly, with each system dependent on the next for physiological equilibrium, but…
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May 4, 2015 0

Tadalafil Citrate (Cialis) Explored

by Mike Arnold With drug-based performance enhancement now being utilized for a multitude of purposes in nearly every sector of society, the idea that one can gain an advantage through pharmaceutical assistance is no longer looked down upon like it once was. With this growing social acceptance, the stigma attached to the use of ED…
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May 4, 2015 0

ACE-083: Myostatin Inhibitor

by Mike Arnold Will this Site Enhancing Wonder Drug Change the Bodybuilding World Forever? After years of immersing myself in the world of PED culture, I have to admit that I have found myself exhibiting decreased levels of interest over every little thing that comes to market. It’s not that I have lost interest in…
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May 4, 2015 0

Letrozole Explored

by Mike Arnold With most of the focus on Aromasin these days, I wanted to bring some of the attention back to our other AI’s. While Aromasin has rightly earned its place on the most popular list, each AI has its own unique set of characteristics which makes it ideal under various circumstances, but before…
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May 4, 2015 0